The current volume entitled, “Free Radicals and Diseases” integrates knowledge in free radical–associated diseases from the basic level to the advanced level, and from the bench side to the bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.

Free radicals are natural by-products of ongoing biochemical reactions in the body, including ordinary metabolic processes and immune system responses. Free radical–generating substances can be found in the food we eat, the drugs and medicines we take, the air we breathe, and the water we drink. Bruce Ames, a well-known scientist in the field of free radicals, estimates that just one cell in the human body is hit about 10,000 times a day by a free radical; when multiplied by the trillions of cells in the body, the damage potential is huge. The past two to three decades have witnessed the remarkable advances in our knowledge about the implication of free radicals in various diseases.

Oxidation is the damage caused by free radicals in the body. Rampaging free radicals react with compounds in the body and oxidize them. The amount of oxidation in the body is the measure of oxidative stress (OS). OS is believed to be the cause of diseases and disorders. This book is a consolidated effort of authors working in the field of oxidative stress to provide comprehensive and up-to-date information on it.

The current opinions on the role of free radical reactions in diabetic cardiomyopathy, polyneuropathy, and neurodegenerative disorders are reported here. Redoxomics and oxidative stress review the “electrophilic stress” as an emerging health risk factor for early aging and many infectious diseases.

The search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. This volume aims to introduce antioxidant activity of herbs. The role of antioxidants in chronic kidney disease is also envisaged. The chapter on novel antioxidant therapy against myocardial ischemia during coronary angioplasty enlightens the knowledge of cardiac interventions.

Since the topic of free radicals and diseases needs extensive research, I also hope that this book will draw the attention of many scientists interested in the field of free radicals.

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